HLA-A and ERBB2

Number of citations of the paper that reports this interaction (PubMedID 10593938)
18

Data Source:
HPRD (in vitro)

		HLA-A	ERBB2
Description		major histocompatibility complex, class I, A	erb-b2 receptor tyrosine kinase 2
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex MHC Class I Peptide Loading Complex Recycling Endosome Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Nucleus Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane ERBB3:ERBB2 Complex Myelin Sheath Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding T Cell Receptor Binding CD8 Receptor Binding TAP Binding TAP Complex Binding	RNA Polymerase I Core Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Protein C-terminus Binding Growth Factor Binding Protein Phosphatase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity
	Biological Process	T Cell Mediated Cytotoxicity T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Positive Regulation Of T Cell Cytokine Production Immune Response Viral Process Protein Ubiquitination Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I CD8-positive, Alpha-beta T Cell Activation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Immune Response T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation	MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Positive Regulation Of Cell Proliferation Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Neuron Differentiation Positive Regulation Of Cell Growth Regulation Of Microtubule-based Process Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Kinase Activity Intracellular Signal Transduction ERBB2 Signaling Pathway Wound Healing Myelination Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase I Protein Autophosphorylation Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of ERBB Signaling Pathway Regulation Of Cell Motility
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling E3 ubiquitin ligases ubiquitinate target proteins Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Signaling by ERBB2 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D induced cell migration and growth-cone collapse RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs		Coccidioides immitis spherule	Trastuzumab Lapatinib IGN311 Trastuzumab emtansine Varlitinib Pertuzumab Afatinib Tucatinib Tesevatinib Brigatinib
Diseases			Choriocarcinoma Pancreatic cancer Gastric cancer Bladder cancer Endometrial Cancer Ovarian cancer Cholangiocarcinoma Breast cancer Cervical cancer
GWAS		Adverse response to carbamazepine ( 21149285) Autism spectrum disorder or schizophrenia ( 28540026) Beta-2 microglubulin plasma levels ( 23417110) Blood protein levels ( 29875488) C-peptide levels in type I diabetes ( 29404672) Carbamazepine-induced maculopapular exanthema ( 29288229) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Change in intraocular pressure in response to steroid treatment (triamcinolone acetonide) ( 25813999) Chickenpox ( 28928442) Childhood ear infection ( 28928442) Chronotype ( 30696823) Cold sores ( 28928442) Complement C3 and C4 levels ( 23028341) Crohn's disease ( 22412388) Drug-induced liver injury (amoxicillin-clavulanate) ( 21570397) Drug-induced liver injury (flucloxacillin) ( 30661239) Frontal fibrosing alopecia ( 30850646) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 27863252) HIV-1 control ( 20041166) IgA nephropathy ( 22197929) IgE levels ( 22075330) Late-onset myasthenia gravis ( 26562150) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Menarche (age at onset) ( 25231870) Mumps ( 28928442) Nasopharyngeal carcinoma ( 19664746 20512145) Plantar warts ( 28928442) Plateletcrit ( 27863252) Red blood cell count ( 27863252) Setpoint viral load in HIV-1 infection ( 26553974) Shingles ( 28928442) Squamous cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 26606652 28714469) Vitiligo ( 20410501 27723757)	Adult asthma ( 30787307) Asthma ( 31619474 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 27329760) Estimated glomerular filtration rate ( 31451708) Pancreatic ductal adenocarcinoma ( 30541042) Polycystic ovary syndrome ( 26416764) Systemic lupus erythematosus ( 26502338 28714469) Ulcerative colitis ( 20228799)
Interacting Genes		26 interacting genes: APLP2 B2M BCAP31 CALR CANX CD8A DEK DERL1 ERBB2 KIR3DL2 LILRB1 LILRB2 MAGEA1 MAGEA4 MEOX2 MEX3C PDIA3 PRKAR1A PRKCA SRC STAT3 TAPBP TRA TRB UBB ZDHHC17	208 interacting genes: ABCB5 ABL1 ABL2 ACP3 ADGRB1 AKT1 ALK ANKS1A ANKS1B ANXA6 APBB1 APBB3 ARNT ATP6AP1 AURKA BCAR3 BECN1 BLK BLNK BMX BTC CALM1 CAV1 CBLC CCND2 CD44 CD82 CDK4 CDK6 CDKN2B CDKN2C CHN1 CISH CLCN6 CLNK CRK CRKL CTNNB1 CXCL8 CYP17A1 DAB1 DDR1 DLG4 DOK1 DOK4 DOK6 DUSP14 DUSP18 DUSP19 EGF EGFR EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHB1 EPHB2 EPHB3 EPHB6 ERBB3 ERBB4 ERBIN ERRFI1 ESR1 FBXO7 FER FGFR1 FGFR2 FGFR3 FGFR4 FGR FLT3 FLT4 FZR1 GAB1 GLCE GLIS2 GMPR2 GRB2 GRB7 GRM1 HDAC6 HDLBP HGF HLA-A HRAS HSP90AA1 HSP90B1 IARS1 IGF1R IL13RA2 IL6ST ILKAP INSR INSRR IRS1 IRS4 ITGA5 ITGB4 ITK JAK1 JAK2 JUP KDELR2 KLK5 LATS2 LYPD3 MAP2K3 MAP2K5 MAPK8IP1 MAPK8IP2 MATK MERTK MET MST1R MTCH1 MUC1 MUC4 MUCL1 MYC NAT2 NCK2 NF2 NRG1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PHF23 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PLCG1 POLD2 PPM1A PPM1F PRDM14 PSAP PSMC3IP PSMD3 PTK2 PTK2B PTK7 PTPN11 PTPN18 PTPN6 PTPRR PTPRT PTPRU RAF1 RASA1 RASSF1 RET RHOBTB2 RIN1 RIN2 ROR2 SERPINA3 SH2B2 SH2B3 SH2D1B SH2D2A SH2D3A SH2D5 SH3BGRL3 SH3BP2 SHC1 SHC2 SHC3 SLA SLA2 SOCS1 SOS1 SRC SRPK1 STAT3 STK11 STK24 STUB1 STYK1 STYX SUPT6H SYK TCEAL2 TEC TGFA THRSP TLN1 TNS2 TNS3 TOB1 TP53 TTC9B TTYH2 TXK TYRO3 UBB USP2 UTP18 VAV1 VAV2 VAV3
Entrez ID		3105	2064
HPRD ID		00826	01281
Ensembl ID		ENSG00000206503	ENSG00000141736
Uniprot IDs		B1PKY1 B2R7U3 P04439 Q5SUL5	F5H1T4 J3QLU9 P04626 X5DNK3
PDB IDs		1AKJ 1AO7 1AQD 1B0G 1B0R 1BD2 1DUY 1DUZ 1EEY 1EEZ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSB 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1JF1 1JHT 1LP9 1OGA 1P7Q 1Q94 1QEW 1QR1 1QRN 1QSE 1QSF 1QVO 1S8D 1S9W 1S9X 1S9Y 1T1W 1T1X 1T1Y 1T1Z 1T20 1T21 1T22 1TMC 1TVB 1TVH 1UR7 1W72 1X7Q 2AV1 2AV7 2BCK 2BNQ 2BNR 2C7U 2CLR 2F53 2F54 2GIT 2GJ6 2GT9 2GTW 2GTZ 2GUO 2HLA 2HN7 2J8U 2JCC 2P5E 2P5W 2PYE 2UWE 2V2W 2V2X 2VLJ 2VLK 2VLL 2VLR 2X4N 2X4O 2X4P 2X4Q 2X4R 2X4S 2X4T 2X4U 2X70 2XPG 3BGM 3BH8 3BH9 3BHB 3BO8 3D25 3D39 3D3V 3FQN 3FQR 3FQT 3FQU 3FQW 3FQX 3FT2 3FT3 3FT4 3GIV 3GJF 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3H7B 3H9H 3H9S 3HAE 3HLA 3HPJ 3I6G 3I6K 3I6L 3IXA 3KLA 3MGO 3MGT 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRI 3MRJ 3MRK 3MRL 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR 3MYJ 3NFN 3O3A 3O3B 3O3D 3O3E 3O4L 3PWJ 3PWL 3PWN 3PWP 3QDG 3QDJ 3QDM 3QEQ 3QFD 3QFJ 3QZW 3REW 3RL1 3RL2 3TO2 3UTQ 3UTS 3UTT 3V5D 3V5H 3V5K 3VXM 3VXN 3VXO 3VXP 3VXR 3VXS 3VXU 3W0W 3WL9 3WLB 4E5X 4EMZ 4EN2 4EUP 4F7M 4F7P 4F7T 4FTV 4GKN 4GKS 4HWZ 4HX1 4I48 4I4W 4JFD 4JFE 4JFF 4JFO 4JFP 4JFQ 4K7F 4L29 4L3C 4L3E 4MJ5 4MJ6 4MNQ 4N8V 4NNX 4NNY 4NO0 4NO2 4NO3 4NO5 4NQV 4NQX 4OV5 4QOK 4U6X 4U6Y 4UQ2 4UQ3 4WJ5 4WU5 4WU7 4WUU 5BRZ 5BS0 5C07 5C08 5C09 5C0A 5C0B 5C0C 5C0D 5C0E 5C0F 5C0G 5C0I 5C0J 5D2L 5D2N 5D9S 5DDH 5E00 5E6I 5E9D 5ENW 5EOT 5EU3 5EU4 5EU5 5EU6 5EUO 5F7D 5F9J 5FA3 5FA4 5FDW 5GRD 5GRG 5GSD 5HGA 5HGB 5HGD 5HGH 5HHM 5HHN 5HHO 5HHP 5HHQ 5HYJ 5IRO 5ISZ 5JHD 5JZI 5MEN 5MEO 5MEP 5MEQ 5MER 5N1Y 5N6B 5NHT 5NME 5NMF 5NMG 5NMH 5NMK 5NQK 5SWQ 5TEZ 5W1W 5WJL 5WJN 5WKF 5WKH 5WSH 5WWI 5WWJ 5WWU 5WXC 5WXD 5XOV 5YXN 5YXU 6AM5 6AMT 6AMU 6APN 6AT9 6D78 6D7G 6DKP 6EI2 6ENY 6EQA 6EQB 6EWA 6EWC 6EWO 6G3J 6G3K 6ID4 6MPP 6NCA 6O9B 6O9C 6OPD 6PTB 6PTE 6Q3K 6Q3S	1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 5K33 5KWG 5MY6 5O4G 5OB4 5TQS 6ATT 6BGT 6J71 6OGE
Enriched GO Terms of Interacting Partners?
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