HIP1 and IFT57

Number of citations of the paper that reports this interaction (PubMedID 11788820)
73

Data Source:
HPRD (two hybrid, in vivo)

		HIP1	IFT57
Description		huntingtin interacting protein 1	intraflagellar transport 57
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Membrane Clathrin-coated Vesicle Actin Cortical Patch Clathrin-coated Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle Presynapse Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse	Golgi Apparatus Centrosome Cilium Axoneme Intraciliary Transport Particle B Photoreceptor Connecting Cilium Ciliary Basal Body Dendrite Terminus Ciliary Tip
	Molecular Function	Epidermal Growth Factor Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Glutamate Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding	DNA Binding Protein Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Protein Kinase B Signaling Membrane Organization Clathrin-dependent Endocytosis Apoptotic Signaling Pathway Neurotransmitter Receptor Transport Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Neural Tube Closure Heart Looping Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Smoothened Signaling Pathway Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Regulation Of Apoptotic Process Motile Cilium Assembly Negative Regulation Of Epithelial Cell Proliferation Left/right Pattern Formation Non-motile Cilium Assembly
Pathways		Clathrin-mediated endocytosis	Hedgehog 'off' state Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Alcoholism (12-month weekly alcohol consumption) ( 21529783) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26961502 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Interleukin-6 levels ( 22205395) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)	Bipolar disorder ( 31043756) Regular attendance at a religious group ( 29970889)
Interacting Genes		25 interacting genes: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CLTA CLTB CLTC DAZAP2 DVL2 EIF6 FBXO25 HIP1R HTT IFT57 ITSN1 MAP3K1 MAPK6 NECAP1 PFDN1 REL RPS10 SMURF1 TFAP2A	4 interacting genes: HIP1 IFT20 UBXN10 ZDHHC17
Entrez ID		3092	55081
HPRD ID		03461	09430
Ensembl ID		ENSG00000127946	ENSG00000114446
Uniprot IDs		B4DK46 O00291	Q9NWB7
PDB IDs		2NO2 2QA7 3I00
Enriched GO Terms of Interacting Partners?
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