HFE and TFRC

Number of citations of the paper that reports this interaction (PubMedID 9465039)
138

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		HFE	TFRC
Description		homeostatic iron regulator	transferrin receptor
Image
GO Annotations	Cellular Component	Extracellular Space Cell Nucleoplasm Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Vesicle MHC Class I Protein Complex Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Terminal Web HFE-transferrin Receptor Complex	Extracellular Region Extracellular Space Cell Endosome Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Melanosome Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle Extracellular Vesicle HFE-transferrin Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Co-receptor Binding Peptide Antigen Binding Transferrin Receptor Binding	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Negative Regulation Of T Cell Antigen Processing And Presentation Negative Regulation Of T Cell Cytokine Production Cellular Iron Ion Homeostasis Acute-phase Response Female Pregnancy Response To Iron Ion Cellular Response To Iron Ion Starvation Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Antigen Processing And Presentation BMP Signaling Pathway Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transferrin Transport Regulation Of Iron Ion Transport Hormone Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Iron Ion Homeostasis Multicellular Organismal Iron Ion Homeostasis Protein-containing Complex Assembly Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Liver Regeneration Iron Ion Import Across Plasma Membrane Negative Regulation Of Receptor Binding Positive Regulation Of Receptor Binding Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Ferrous Iron Binding Positive Regulation Of Transferrin Receptor Binding Response To Iron Ion Starvation Regulation Of Protein Localization To Cell Surface Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Signaling Receptor Activity Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation	Regulation Of Cell Growth Positive Regulation Of Protein Phosphorylation Iron Ion Transport Cellular Iron Ion Homeostasis Positive Regulation Of Gene Expression Osteoclast Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Complex Assembly Receptor Internalization Positive Regulation Of Peptidyl-serine Phosphorylation Transferrin Transport Cellular Response To Drug Positive Regulation Of T Cell Proliferation Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Bone Resorption Positive Regulation Of Isotype Switching Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Membrane Organization Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor
Pathways		Transferrin endocytosis and recycling	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Transferrin endocytosis and recycling
Drugs			Iron
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Autism spectrum disorder or schizophrenia ( 28540026) Blood pressure ( 21909110) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 24097068 20686565) Diastolic blood pressure ( 27841878 21909115 28739976 27618447 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling guilty ( 29500382) Glycated hemoglobin levels ( 20858683 28898252) Hematocrit ( 27863252 28017375 19862010) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 19820698 28453575 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) Hepcidin levels ( 21785125) Hepcidin/ferritin ratio ( 27846281) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 21909115) Intelligence (MTAG) ( 29326435) Iron status biomarkers ( 25224454 21483845 21149283 21208937 19820699 19084217) Iron status biomarkers (ferritin levels) ( 28334935 25352340) Iron status biomarkers (iron levels) ( 28334935 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935 25352340) LDL cholesterol ( 24097068 20686565) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 23263863 29403010 19853236 28453575 28017375) Mean corpuscular hemoglobin concentration ( 29403010 27863252 28017375) Mean corpuscular volume ( 20139978 28017375 19862010) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Number of sexual partners ( 30643258) Osteoarthritis (hip) ( 30374069) Platelet count ( 27863252) Red blood cell count ( 27863252) Red blood cell traits ( 23446634 20927387 23222517) Red cell distribution width ( 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Schizophrenia ( 30285260) Systolic blood pressure ( 27841878 21909115 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Worry too long after an embarrassing experience ( 29500382)	Asthma ( 30929738) Asthma (adult onset) ( 30929738) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340) Mean corpuscular hemoglobin ( 28453575 20139978 27863252 19862010) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 28453575 20139978 27863252 19862010) Neurofibrillary tangles ( 31497858) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		3 interacting genes: B2M TFR2 TFRC	12 interacting genes: ACAP1 B4GALT1 CD247 CD4 GABARAP HFE LMNA RAB5B RAB8A RANBP9 SGTA TF
Entrez ID		3077	7037
HPRD ID		01993	01812
Ensembl ID		ENSG00000010704	ENSG00000072274
Uniprot IDs		B4DV50 F8W7W8 Q30201	A8K6Q8 B7Z2I6 G3V0E5 P02786 Q7Z3E0
PDB IDs		1A6Z 1C42 1DE4	1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N 6D03 6D04 6D05 6GSR 6H5I
Enriched GO Terms of Interacting Partners?
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