HCRTR1 and CNR1

Number of citations of the paper that reports this interaction (PubMedID 12690115)
32

Data Source:
HPRD (in vivo)

		HCRTR1	CNR1
Description		hypocretin receptor 1	cannabinoid receptor 1
Image
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Synapse	Mitochondrial Outer Membrane Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton Cell Junction Growth Cone Integral Component Of Mitochondrial Membrane Membrane Raft Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Orexin Receptor Activity Peptide Hormone Binding Peptide Binding	Cannabinoid Receptor Activity Protein Binding Drug Binding Identical Protein Binding Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERK1 And ERK2 Cascade	Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Axonal Fasciculation Aging Response To Nutrient Memory Positive Regulation Of Neuron Projection Development Negative Regulation Of Serotonin Secretion Sensory Perception Of Pain Positive Regulation Of Fever Generation Negative Regulation Of Fatty Acid Beta-oxidation Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Negative Regulation Of Mast Cell Activation Negative Regulation Of Dopamine Secretion Response To Nicotine Cannabinoid Signaling Pathway Response To Cocaine Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Negative Regulation Of Action Potential Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Regulation Of Insulin Secretion Negative Regulation Of Nitric-oxide Synthase Activity Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Regulation Of Penile Erection Retrograde Trans-synaptic Signaling By Endocannabinoid Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs		Suvorexant	Dronabinol Nabilone Ricinoleic Acid SLV319 V24343 CP-945598 AVE-1625 Rimonabant
Diseases
GWAS		Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) General cognitive ability ( 29844566)	Depression in smokers ( 30219690) Gut microbiota (functional units) ( 27694959)
Interacting Genes		6 interacting genes: ARRB1 ARRB2 ATP1B1 CNR1 HCRT PABPC4	7 interacting genes: GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET SSTR5
Entrez ID		3061	1268
HPRD ID		03863	00259
Ensembl ID		ENSG00000121764	ENSG00000118432
Uniprot IDs		A6NMV7 O43613	P21554 S5TLS4 V5KA96
PDB IDs		4ZJ8 4ZJC	1LVQ 1LVR 2B0Y 2KOE 2MZ2 2MZ3 2MZA 5TGZ 5U09 5XR8 5XRA 6KQI 6N4B
Enriched GO Terms of Interacting Partners?
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