HCK and KRTAP10-9

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		HCK	KRTAP10-9
Description		HCK proto-oncogene, Src family tyrosine kinase	keratin associated protein 10-9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Lysosome Golgi Apparatus Cytosol Actin Filament Plasma Membrane Caveola Focal Adhesion Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Projection	Cytosol Keratin Filament
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Protein Binding
	Biological Process	Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signal Transduction Protein Phosphorylation Inflammatory Response Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Leukocyte Degranulation Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Defense Response To Virus By Virus Regulation Of Inflammatory Response Regulation Of Phagocytosis Regulation Of DNA-binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Podosome Assembly Positive Regulation Of Actin Cytoskeleton Reorganization	Keratinization
Pathways		Nef and signal transduction FCGR activation Regulation of signaling by CBL Regulation of signaling by CBL FLT3 Signaling FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis	Keratinization
Drugs		1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 23128233) Migraine ( 27322543)
Interacting Genes		78 interacting genes: ABL1 ABL2 ACTB ADAM15 AGK APP ARRB1 ASAP1 BCAR1 BCR BTK CBL CCR3 CD2AP CHST15 COMT CREBBP CSF2RB CSF3R CSK DNM2 DOK1 DOK2 EGFR ELMO1 ERBB3 EVL FASLG FCGR1A FCGR2A FHL2 GOPC GRB14 HNRNPK IL6ST INPP5D IRF2BPL KHDRBS1 KIT KRT40 KRTAP10-9 LCP2 LETMD1 LMNA MAP4K5 MDM2 MTUS2 NGEF NOTCH2NLA PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 RAPGEF1 RASA1 RASA3 RPL10 SF3B3 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TNK2 TP73 TRPV4 TSG101 UNC119 VAV1 WAS WDCP WIPF1 WNT2	165 interacting genes: ADAMTSL4 ALDH3B1 ALPI ARFGAP1 ATXN7L1 AVPI1 BCL6B C10orf62 C11orf87 C19orf57 C5orf60 CATIP CATSPER1 CBX2 CCDC26 CD300LG CDKL3 CHIC2 CHRD CHRNG CKS1B CLK4 CNNM3 CRCT1 CREB5 CST9L CXCL16 DHX57 DMRT3 DOCK2 EIF4E2 FAM124B FAM161A FAM74A4 FAM76B FARS2 GABARAPL1 GABARAPL2 GATA2 GLIDR GLP1R GLRX3 GNE GPATCH2L GSTP1 HBG1 HBZ HCK HOXA1 HOXB9 HPCAL1 HSD3B7 IGSF8 INPP5D IQUB ITGB5 KAT5 KIF9 KLHL38 KRT20 KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-1 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE2D LCE3C LCE3E LCE4A LUZP4 MAB21L3 MAPKBP1 MED30 MEOX2 MOBP MT1DP MXI1 NAXD NECTIN3 NOTCH2NLA NPBWR2 NPDC1 NPPB NR1D2 NUFIP2 OTX1 PGAP2 PGLS PIN1 PLSCR1 PRKAB2 PRPF31 PTGER3 PVR RAB7A RHNO1 RSPO2 SCARB1 SCNM1 SHFL SLC23A1 SLC6A20 SMARCE1 SMCP SPACA9 SPATA3 SPATA8 SPG7 SPRY1 SPRY2 STK16 TBC1D16 TBC1D23 TEDC2 TGOLN2 THAP10 TLE5 TNFRSF6B TNP2 TRIM41 TRIM42 TXNDC5 TYMSOS TYRO3 UTP23 WNT11 WT1 WT1-AS XCL2 ZBTB24 ZBTB38 ZBTB9 ZFYVE26 ZNF124 ZNF155 ZNF20 ZNF264 ZNF317 ZNF417 ZNF439 ZNF440 ZNF473 ZNF564 ZNF572 ZNF578 ZNF581 ZNF587 ZNF625 ZNF688 ZNF697 ZNF699 ZNF792 ZNF844 ZSCAN21 ZSCAN26
Entrez ID		3055	386676
HPRD ID		00796	11195
Ensembl ID		ENSG00000101336	ENSG00000221837
Uniprot IDs		A8K4G3 P08631	P60411
PDB IDs		1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 4LUD 4LUE 4ORZ 4U5W 5H09 5H0B 5H0E 5H0G 5H0H 5HCK 5NUH 5ZJ6
Enriched GO Terms of Interacting Partners?
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