H2AZ1 and FH

Number of citations of the paper that reports this interaction (PubMedID 26237645)
44

Data Source:
BioGRID (pull down)

		H2AZ1	FH
Description		H2A.Z variant histone 1	fumarate hydratase
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GO Annotations	Cellular Component	Nucleosome Nuclear Chromatin Barr Body Nucleus Nuclear Euchromatin Nuclear Heterochromatin Extracellular Exosome	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Tricarboxylic Acid Cycle Enzyme Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity	Fumarate Hydratase Activity Protein Binding
	Biological Process	Chromatin Organization Chromatin Silencing Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus	Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Deposition of new CENPA-containing nucleosomes at the centromere RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Amyloid fiber formation	Citric acid cycle (TCA cycle)
Drugs
Diseases			Renal cell carcinoma Multiple cutaneous and uterine leiomyomata Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS			Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)
Interacting Genes		7 interacting genes: FH INCENP MAGEC1 NCAPH RNF168 RNF169 USP16	6 interacting genes: CCNDBP1 GRB2 H2AZ1 MDH2 PIM1 PRKDC
Entrez ID		3015	2271
HPRD ID		00823	00652
Ensembl ID		ENSG00000164032	ENSG00000091483
Uniprot IDs		P0C0S5	A0A0S2Z4C3 P07954
PDB IDs		1F66 3WA9 4CAY 4NFT 5B31 5B32 5B33 5CHL 5FUG 5Z30	3E04 5D6B 5UPP 6EBT
Enriched GO Terms of Interacting Partners?
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