H1-0 and PARP2

Number of citations of the paper that reports this interaction (PubMedID 28190768)
52

Data Source:
BioGRID (enzymatic study)

		H1-0	PARP2
Description		H1.0 linker histone	poly(ADP-ribose) polymerase 2
Image
GO Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Nuclear Euchromatin Golgi Apparatus Actin Cytoskeleton Nuclear Body Transcriptional Repressor Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	AT DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Protein ADP-ribosylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation Nucleosome Assembly Chromatin Silencing Regulation Of Transcription, DNA-templated Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Positive Regulation Of Transcription Regulatory Region DNA Binding	DNA Repair Base-excision Repair Double-strand Break Repair Protein ADP-ribosylation Peptidyl-serine ADP-ribosylation DNA ADP-ribosylation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Death
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs			Veliparib Olaparib Niraparib Rucaparib
Diseases
GWAS			Menopause (age at onset) ( 26414677)
Interacting Genes		21 interacting genes: APP CCNE1 CDK1 CDK2 CDK4 CDK5 FBXO7 GRB2 HPF1 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PARP1 PARP2 PRKCB RAD51B XBP1	13 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 XRCC1
Entrez ID		3005	10038
HPRD ID		00819	09660
Ensembl ID		ENSG00000189060	ENSG00000129484
Uniprot IDs		P07305	Q9UGN5
PDB IDs		6HQ1 6N88 6N89	3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F
Enriched GO Terms of Interacting Partners?
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