GRM1 and HOMER2

Number of citations of the paper that reports this interaction (PubMedID 9808458)
189

Data Source:
HPRD (in vitro)

		GRM1	HOMER2
Description		glutamate metabotropic receptor 1	homer scaffold protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Plasma Membrane Integral Component Of Plasma Membrane Dendrite G Protein-coupled Receptor Dimeric Complex G Protein-coupled Receptor Homodimeric Complex Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Junction Dendrite Stereocilium Tip Neuron Projection Neuronal Cell Body Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	Actin Binding Protein Binding Protein Domain Specific Binding GKAP/Homer Scaffold Activity G Protein-coupled Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity G Protein-coupled Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Sensory Perception Of Pain Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Sensory Perception Of Pain Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Electrical Stimulus Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	G Protein-coupled Glutamate Receptor Signaling Pathway Sensory Perception Of Sound Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Negative Regulation Of Interleukin-2 Production Calcium-mediated Signaling Using Intracellular Calcium Source Behavioral Response To Cocaine Chemical Homeostasis Within A Tissue Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry
Pathways		G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Glutamic Acid 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Suicide ( 31476763) Waist circumference ( 29212154)	Tourette syndrome ( 30818990)
Interacting Genes		38 interacting genes: ADORA1 BECN1 CABIN1 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C EFNB2 EPB41L2 EPHA2 ERBB2 FGFR4 GAPDH GPRASP1 GRK2 HOMER1 HOMER2 IGF1R ITPR1 KAT2A KDELR2 LATS2 MAP2K5 MYC NF2 OPTN PDGFRA PRKCA RAF1 RASSF1 STK11 TAMALIN TERT TTYH2 TUBB	12 interacting genes: AGAP2 APP DBN1 GRM1 ITPR1 KPNA2 LZTS2 PJA1 RYR1 SMURF1 UBXN1 VKORC1
Entrez ID		2911	9455
HPRD ID		05129	07269
Ensembl ID		ENSG00000152822	ENSG00000103942
Uniprot IDs		Q13255 Q59HC2	Q9NSB8
PDB IDs		3KS9 4OR2
Enriched GO Terms of Interacting Partners?
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