PYCARD and NLRP12

Number of citations of the paper that reports this interaction (PubMedID 12019269)
117

Data Source:
HPRD (in vivo)

		PYCARD	NLRP12
Description		PYD and CARD domain containing	NLR family pyrin domain containing 12
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol IkappaB Kinase Complex Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Neuronal Cell Body NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Nucleus Cytoplasm
	Molecular Function	Protease Binding Interleukin-6 Receptor Binding Protein Binding Tropomyosin Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Myosin I Binding Enzyme Binding Pyrin Domain Binding Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding Protein Dimerization Activity BMP Receptor Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1 Beta Production Negative Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Macropinocytosis Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Defense Response To Virus Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Chemokine Secretion Positive Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of T Cell Migration Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Dendritic Cell Migration Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MHC Class I Biosynthetic Process Regulation Of Interleukin-18 Biosynthetic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Negative Regulation Of Toll Signaling Pathway Negative Regulation Of Cytokine Secretion Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		CLEC7A/inflammasome pathway Neutrophil degranulation The NLRP3 inflammasome The AIM2 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS		Post bronchodilator FEV1 ( 26634245)	Blood protein levels ( 29875488) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Testicular germ cell tumor ( 28604728)
Interacting Genes		12 interacting genes: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 SRF USP50	3 interacting genes: FAF1 IRAK1 PYCARD
Entrez ID		29108	91662
HPRD ID		06020	14803
Ensembl ID		ENSG00000103490	ENSG00000142405
Uniprot IDs		Q9ULZ3	P59046
PDB IDs		1UCP 2KN6 3J63 5H8O 6N1H	2L6A 4XHS 5H7N
Enriched GO Terms of Interacting Partners?
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