ACAD9 and ISY1

		ACAD9	ISY1
Description		acyl-CoA dehydrogenase family member 9	ISY1 splicing factor homolog
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Dendrite Mitochondrial Membrane	Prp19 Complex Nucleus Nucleoplasm U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex Post-spliceosomal Complex
	Molecular Function	Fatty-acyl-CoA Binding Long-chain-acyl-CoA Dehydrogenase Activity Protein Binding Very-long-chain-acyl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding Medium-chain-acyl-CoA Dehydrogenase Activity	RNA Binding Protein Binding
	Biological Process	Long-chain Fatty Acid Metabolic Process Mitochondrial Respiratory Chain Complex I Assembly Medium-chain Fatty Acid Metabolic Process Oxidation-reduction Process	Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair
Pathways		Complex I biogenesis	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Dental caries ( 23064961) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: H1-10 HMCES ISY1 SEC61A1 TMCC1	2 interacting genes: ACAD9 XAB2
Entrez ID		28976	57461
HPRD ID		12412	13834
Ensembl ID		ENSG00000177646	ENSG00000240682
Uniprot IDs		Q9H845	Q9ULR0
PDB IDs			5YZG 6FF7
Enriched GO Terms of Interacting Partners?
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