DCPS and GPC5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		DCPS	GPC5
Description		decapping enzyme, scavenger	glypican 5
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Extracellular Region Extracellular Space Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Lysosomal Lumen Anchored Component Of Plasma Membrane Collagen-containing Extracellular Matrix
	Molecular Function	RNA 7-methylguanosine Cap Binding Exoribonuclease Activity Protein Binding M7G(5')pppN Diphosphatase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cellular Response To Menadione Negative Regulation Of Programmed Cell Death Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay MRNA Cis Splicing, Via Spliceosome RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cell Migration Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Membrane
Pathways		mRNA decay by 3' to 5' exoribonuclease	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Release of Hh-Np from the secreting cell Retinoid metabolism and transport
Drugs		7-Methyl-Gpppa 7n-Methyl-8-Hydroguanosine-5'-Diphosphate N7-Methyl-Guanosine-5'-Monophosphate 7-methyl-guanosine-5'-triphosphate-5'-guanosine 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine
Diseases
GWAS		Neutrophil percentage of white cells ( 27863252)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Blood pressure (smoking interaction) ( 25189868) Blood protein levels ( 30072576 29875488 28240269) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 20881960 25282103 25429064 20189936) HIV-1 viral setpoint ( 20205591) Incident coronary heart disease ( 26950853) Lung cancer ( 20304703) Metabolite levels ( 23823483 19043545) Multiple sclerosis ( 19010793) Nephrotic syndrome (acquired) ( 21441931) Neurological blood protein biomarker levels ( 31320639) Obesity-related traits ( 23251661) Rapid automised naming of letters ( 30741946) Refractive astigmatism ( 30306274) Rheumatoid arthritis ( 30423114) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Tetralogy of Fallot ( 23297363) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		7 interacting genes: CDC20 CDC27 CHST4 CSNK2A2 FZR1 GPC5 YWHAQ	1 interacting genes: DCPS
Entrez ID		28960	2262
HPRD ID		16787	03902
Ensembl ID		ENSG00000110063	ENSG00000179399
Uniprot IDs		A0A384MTI8 Q96C86	P78333
PDB IDs		1ST0 1ST4 1XML 1XMM 3BL7 3BL9 3BLA 4QDE 4QDV 4QEB 5OSY
Enriched GO Terms of Interacting Partners?
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