NKIRAS1 and XRCC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		NKIRAS1	XRCC2
Description		NFKB inhibitor interacting Ras like 1	X-ray repair cross complementing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm	Nucleoplasm Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activity GTP Binding	Four-way Junction DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity
	Biological Process	I-kappaB Kinase/NF-kappaB Signaling	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis DNA Repair Centrosome Cycle Response To X-ray Response To Gamma Radiation Multicellular Organism Growth Strand Invasion Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Meiotic Cell Cycle Regulation Of Fibroblast Apoptotic Process
Pathways		RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435)	Diabetic kidney disease ( 26305897) Mean platelet volume ( 27863252) Palmitic acid (16:0) levels ( 23362303)
Interacting Genes		8 interacting genes: ACVR1 APP BMPR1B NFKBIA NFKBIB SMURF2 TGFBR1 XRCC2	5 interacting genes: MEOX2 NKIRAS1 RAD51 RAD51D WFDC1
Entrez ID		28512	7516
HPRD ID		06841	02656
Ensembl ID		ENSG00000197885	ENSG00000196584
Uniprot IDs		Q9NYS0	A0A384MEK2 O43543
PDB IDs
Enriched GO Terms of Interacting Partners?
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