IFNL2 and IFNLR1

Number of citations of the paper that reports this interaction (PubMedID 12469119)
445

Data Source:
HPRD (in vivo)

		IFNL2	IFNLR1
Description		interferon lambda 2	interferon lambda receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Membrane Interleukin-28 Receptor Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity	Cytokine Receptor Activity Protein Binding
	Biological Process	Mucosal Immune Response JAK-STAT Cascade Cytokine-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Immune Response Defense Response To Virus	Mucosal Immune Response Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Response To Type III Interferon Regulation Of Defense Response To Virus By Host Defense Response To Virus
Pathways		Interleukin-20 family signaling	Other interleukin signaling Interleukin-20 family signaling
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325)	Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory skin disease ( 25574825) Molybdenum levels ( 26025379) Psoriasis vulgaris ( 26626624)
Interacting Genes		2 interacting genes: IFNLR1 IL10RB	3 interacting genes: IFNL1 IFNL2 LSM8
Entrez ID		282616	163702
HPRD ID		09586	09589
Ensembl ID		ENSG00000183709	ENSG00000185436
Uniprot IDs		Q8IZJ0	Q8IU57
PDB IDs			3OG4 3OG6 5IXD 5IXI 5L04 5T5W
Enriched GO Terms of Interacting Partners?
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