GOT1 and PC

Number of citations of the paper that reports this interaction (PubMedID 8349677)
3

Data Source:
BioGRID (pull down)

		GOT1	PC
Description		glutamic-oxaloacetic transaminase 1	pyruvate carboxylase
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GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Axon Terminus Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine:2-oxoglutarate Aminotransferase Activity	Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Notch Signaling Pathway Cellular Amino Acid Biosynthetic Process Response To Carbohydrate Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Immobilization Stress Response To Cadmium Ion Response To Glucocorticoid Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Fatty Acid Homeostasis Transdifferentiation Cellular Response To Mechanical Stimulus Response To Transition Metal Nanoparticle	Pyruvate Metabolic Process Gluconeogenesis Lipid Metabolic Process Biotin Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Process
Pathways		Methionine salvage pathway Gluconeogenesis Aspartate and asparagine metabolism	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis
Drugs		Pyridoxal Phosphate L-Aspartic Acid Glutamic Acid L-Cysteine Maleic Acid Copper	Pyruvic acid Biotin 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL
Diseases			Pyruvate carboxylase deficiency
GWAS		Aspartate aminotransferase levels ( 30718733 21900944) Crohn's disease ( 22412388) Hypothyroidism ( 27182965) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean corpuscular volume ( 29403010)	Bipolar disorder ( 21926972 31043756) Familial squamous cell lung carcinoma ( 29924316) HIV-1 susceptibility ( 22174851) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: ABI3BP EGFR PC TMEM120A	3 interacting genes: GOT1 GOT2 MDH2
Entrez ID		2805	5091
HPRD ID		00687	02032
Ensembl ID		ENSG00000120053	ENSG00000173599
Uniprot IDs		A0A140VK69 P17174	A0A024R5C5 P11498
PDB IDs		3II0 3WZF 6DNA 6DNB 6DND	3BG3 3BG9
Enriched GO Terms of Interacting Partners?
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