POLL and UBE2H

Number of citations of the paper that reports this interaction (PubMedID 17588522)
59

Data Source:
BioGRID (enzymatic study)

		POLL	UBE2H
Description		DNA polymerase lambda	ubiquitin conjugating enzyme E2 H
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytosol
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Metal Ion Binding 5'-deoxyribose-5-phosphate Lyase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication Base-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Somatic Hypermutation Of Immunoglobulin Genes DNA Biosynthetic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Nonhomologous End-Joining (NHEJ)	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 31152163 31451708) Response to antidepressants and depression ( 27622933)
Interacting Genes		23 interacting genes: APP CDK2 FAM9B FSD2 HUWE1 KRT40 KRTAP10-3 KRTAP10-7 LDOC1 MAGEA12 PCNA PNMA1 REV1 RPA1 SSX2IP TFCP2 TFIP11 TRIM23 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H	67 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 UBA1 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		27343	7328
HPRD ID		09394	03052
Ensembl ID		ENSG00000166169	ENSG00000186591
Uniprot IDs		A8K860 B4DE17 Q9UGP5	A0A3B3IU20 A4D1L5 P62256
PDB IDs		1NZP 1RZT 1XSL 1XSN 1XSP 2BCQ 2BCR 2BCS 2BCU 2BCV 2GWS 2JW5 2PFN 2PFO 2PFP 2PFQ 3C5F 3C5G 3HW8 3HWT 3HX0 3MDA 3MDC 3MGH 3MGI 3PML 3PMN 3PNC 3UPQ 3UQ0 3UQ2 4FO6 4K4G 4K4H 4K4I 4X5V 4XA5 4XQ8 4XRH 4XUS 5CA7 5CB1 5CHG 5CJ7 5CP2 5CR0 5CWR 5DDM 5DDY 5DKW 5III 5IIJ 5IIK 5IIL 5IIM 5IIN 5IIO 5W4G	2Z5D
Enriched GO Terms of Interacting Partners?
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