PDCD4 and RPS13

Number of citations of the paper that reports this interaction (PubMedID 12054647)
12

Data Source:
HPRD (two hybrid, in vitro)

		PDCD4	RPS13
Description		programmed cell death 4	ribosomal protein S13
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Small Ribosomal Subunit Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding MRNA 5'-UTR Binding Small Ribosomal Subunit RRNA Binding
	Biological Process	Apoptotic Process Cell Aging BMP Signaling Pathway Interleukin-12-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Inflammatory Response Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Cellular Response To Lipopolysaccharide Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Endothelial Cell Apoptotic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Negative Regulation Of RNA Splicing
Pathways		Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Artenimol
Diseases
GWAS			Body mass index ( 26426971) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		14 interacting genes: APOE BTRC CSNK2A1 EIF4A3 EIF4G1 IBTK LRRK1 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1 SKP2	5 interacting genes: MAP3K14 NFKB2 PDCD4 PTEN SPP1
Entrez ID		27250	6207
HPRD ID		10549	01604
Ensembl ID		ENSG00000150593	ENSG00000110700
Uniprot IDs		B4DKX4 Q53EL6	P62277
PDB IDs		2GGF 2KZT 2RG8 2ZU6 3EIJ	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
Enriched GO Terms of Interacting Partners?
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