CHMP2A and EIF2B5

Number of citations of the paper that reports this interaction (PubMedID 16730941)
60

Data Source:
HPRD (two hybrid)

		CHMP2A	EIF2B5
Description		charged multivesicular body protein 2A	eukaryotic translation initiation factor 2B subunit epsilon
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin ESCRT III Complex Cell Nuclear Envelope Multivesicular Body Cytosol Membrane Membrane Coat Late Endosome Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding Phosphatidylcholine Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Nucleus Organization Mitotic Metaphase Plate Congression Membrane Invagination Exit From Mitosis Regulation Of Centrosome Duplication Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Nuclear Envelope Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Establishment Of Protein Localization Late Endosome To Vacuole Transport Regulation Of Viral Process Protein Polymerization Protein Homooligomerization Negative Regulation Of Cell Death Midbody Abscission Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Positive Regulation Of Exosomal Secretion Negative Regulation Of Centriole Elongation ESCRT III Complex Disassembly	Ovarian Follicle Development Translational Initiation Aging Response To Heat Response To Glucose Response To Lithium Ion Astrocyte Development Oligodendrocyte Development Hippocampus Development Response To Endoplasmic Reticulum Stress Myelination Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Translational Initiation Astrocyte Differentiation T Cell Receptor Signaling Pathway
Pathways		Budding and maturation of HIV virion Macroautophagy Lysosome Vesicle Biogenesis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III	Recycling of eIF2:GDP
Drugs
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS			General cognitive ability ( 29844566) Immature fraction of reticulocytes ( 27863252) Major depressive disorder ( 22472876) Platelet count ( 27863252) Plateletcrit ( 27863252)
Interacting Genes		21 interacting genes: CHD3 CHMP3 CYP4F2 DOCK8 E2F4 EIF2B5 ITGA5 KERA MAPKAPK3 MITD1 NCOA1 NOL4 SLC25A1 STAMBP TGFB3 UFD1 USP54 USP8 VPS4A VPS4B ZNF32	11 interacting genes: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 DYRK1A DYRK2 EIF2B2 EIF2S2 GSK3A GSK3B
Entrez ID		27243	8893
HPRD ID		12520	04898
Ensembl ID		ENSG00000130724	ENSG00000145191
Uniprot IDs		A0A024R4S0 O43633	Q13144
PDB IDs			3JUI 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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