DKK3 and IDH1

Number of citations of the paper that reports this interaction (PubMedID 27229929)
3

Data Source:
BioGRID (two hybrid)

		DKK3	IDH1
Description		dickkopf WNT signaling pathway inhibitor 3	isocitrate dehydrogenase (NADP(+)) 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Region Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Co-receptor Binding Receptor Antagonist Activity	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Identical Protein Binding Protein Homodimerization Activity Cadherin Binding NADP Binding NAD Binding
	Biological Process	Anatomical Structure Morphogenesis Wnt Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Adrenal Gland Development Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anti-Mullerian Hormone Signaling Pathway Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Signaling Receptor Activity	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process Protein Targeting To Peroxisome NADP Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Neutrophil Degranulation Response To Steroid Hormone Regulation Of Phospholipid Catabolic Process Regulation Of Phospholipid Biosynthetic Process
Pathways			Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import
Drugs			Isocitric Acid 2'-Monophosphoadenosine 5'-Diphosphoribose
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933) Response to perphenazine in schizophrenia ( 29503163) Response to taxane treatment (docetaxel) ( 23006423) Visceral fat ( 22589738)	Cerebral amyloid deposition (PET imaging) ( 30361487) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443)
Interacting Genes		9 interacting genes: APC AURKA BCAR3 ESR2 FZR1 IDH1 PPM1D SMAD4 UBQLN4	14 interacting genes: AGGF1 CRACR2B DKK3 FAM131A FHL2 FIGNL1 LAX1 NUP62 PEX5 PRDM14 SUMO4 TMOD4 UBL7 ZHX1
Entrez ID		27122	3417
HPRD ID		05659	00984
Ensembl ID		ENSG00000050165	ENSG00000138413
Uniprot IDs		F6SYF8 Q9UBP4	A0A024R3Y6 O75874
PDB IDs			1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06 4UMX 4UMY 4XRX 4XS3 5DE1 5GIR 5K10 5K11 5L57 5L58 5LGE 5SUN 5SVF 5TQH 5YFM 5YFN 6ADG 6B0Z 6BKX 6BKY 6BKZ 6BL0 6BL1 6BL2 6IO0 6O2Y 6O2Z 6PAY 6Q6F
Enriched GO Terms of Interacting Partners?
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