DAPP1 and HSD3B7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		DAPP1	HSD3B7
Description		dual adaptor of phosphotyrosine and 3-phosphoinositides 1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Membrane
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding	3-beta-hydroxy-delta5-steroid Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase Activity
	Biological Process	Protein Dephosphorylation Signal Transduction	Bile Acid Biosynthetic Process B Cell Chemotaxis Oxidation-reduction Process
Pathways		Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs		Inositol 1,3,4,5-Tetrakisphosphate
Diseases			Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC) Congenital bile acid synthesis defect (CBAS), including: 3-beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency (CBAS1); Delta(4)-3-oxosteroid 5-beta-reductase deficiency (CBAS2); Oxysterol 7-alpha-hydroxylase deficiency (CBAS3); Alpha-methylacyl-CoA racemase deficiency (CBAS4)
GWAS
Interacting Genes		21 interacting genes: BTK CNDP2 ERBB3 FCHSD2 GSTCD HSD3B7 HSPA1A LCK LYN MAP4K1 MGARP MYLIP PLAGL2 PLCG1 PLCG2 RBP7 RPL23 SRC TM4SF19 TNFAIP1 ZNHIT1	11 interacting genes: DAPP1 ICAM1 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 NOTCH2NLA PYGL SPRY2
Entrez ID		27071	80270
HPRD ID		05773	09680
Ensembl ID		ENSG00000070190	ENSG00000099377
Uniprot IDs		J3KNB3 Q9UN19	Q9H2F3
PDB IDs		1FAO 1FB8
Enriched GO Terms of Interacting Partners?
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