GJB2 and GJB6

Number of citations of the paper that reports this interaction (PubMedID 14595769)
94

Data Source:
HPRD (in vivo)

		GJB2	GJB6
Description		gap junction protein beta 2	gap junction protein beta 6
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Connexin Complex Lateral Plasma Membrane Cell Body Perinuclear Region Of Cytoplasm Astrocyte Projection	Cell Cytosol Actin Filament Gap Junction Connexin Complex Integral Component Of Membrane Apical Plasma Membrane Cell Junction
	Molecular Function	Gap Junction Channel Activity Calcium Ion Binding Identical Protein Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling	Gap Junction Channel Activity Microtubule Binding Beta-tubulin Binding Actin Filament Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process	Response To Ischemia Cell-cell Signaling Aging Sensory Perception Of Sound Cell Communication By Electrical Coupling Gap Junction Assembly Response To Estradiol Response To Lipopolysaccharide Response To Retinoic Acid Response To Progesterone Cellular Response To Oxidative Stress Response To Human Chorionic Gonadotropin Response To Antibiotic Decidualization Inner Ear Development Transmembrane Transport Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Epididymis Development Gap Junction-mediated Intercellular Transport	Apoptotic Process Aging Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Cell Communication By Electrical Coupling Gap Junction Assembly Response To Lipopolysaccharide Ear Morphogenesis Inner Ear Development Response To Electrical Stimulus Transmembrane Transport Cellular Response To Glucose Stimulus Gap Junction-mediated Intercellular Transport
Pathways		Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly Transport of connexons to the plasma membrane	Gap junction assembly
Drugs
Diseases		Keratitis-ichthyosis-deafness syndrome Palmoplantar keratoderma with deafness Deafness, autosomal dominant Deafness, autosomal recessive Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis	Ectodermal dysplasia, hidrotic; Clouston syndrome Deafness, autosomal recessive
GWAS		Facial emotion recognition (happy faces) ( 28608620)	Facial emotion recognition (happy faces) ( 28608620)
Interacting Genes		8 interacting genes: CAV1 CD14 CNST CREB3 GJB1 GJB6 LMNA NGLY1	2 interacting genes: CNST GJB2
Entrez ID		2706	10804
HPRD ID		00413	05107
Ensembl ID		ENSG00000165474	ENSG00000121742
Uniprot IDs		H9U1J4 P29033	A0A024RDS4 O95452
PDB IDs		1XIR 2ZW3 3IZ1 3IZ2 5ER7 5ERA 5KJ3 5KJG
Enriched GO Terms of Interacting Partners?
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