PELP1 and H3-3A

Number of citations of the paper that reports this interaction (PubMedID 27626385)
36

Data Source:
BioGRID (pull down)

		PELP1	H3-3A
Description		proline, glutamate and leucine rich protein 1	H3.3 histone A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Transcriptionally Active Chromatin MLL1 Complex	Nuclear Chromosome Nuclear Chromosome, Telomeric Region Nucleosome Nuclear Nucleosome Barr Body Extracellular Region Nucleus Nucleoplasm Protein-containing Complex Extracellular Exosome
	Molecular Function	Chromatin Binding RNA Binding Protein Binding Transcription Factor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	RRNA Processing Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estrogen Stimulus	Chromatin Silencing At RDNA Osteoblast Differentiation Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Nucleus Organization Spermatid Development Single Fertilization Embryo Implantation Blood Coagulation Cell Proliferation Male Gonad Development Positive Regulation Of Cell Growth Pericentric Heterochromatin Assembly Telomeric Heterochromatin Assembly Telomere Organization Multicellular Organism Growth Muscle Cell Differentiation Cellular Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Oogenesis Regulation Of Gene Silencing By MiRNA Regulation Of Centromere Complex Assembly Negative Regulation Of Chromosome Condensation
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol PTK6 Expression	Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Amyloid fiber formation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Eosinophil counts ( 29403010)
Interacting Genes		24 interacting genes: AR BAG6 BCAS3 BLOC1S1 CREBBP EP300 ESR1 ESR2 H1-1 H2AC20 H2BC21 H3-3A H4C1 HGS NFKB1 NR3C1 RB1 SMAD9 SNCA SRC STAT3 SUMO2 TOM1L1 TP53	38 interacting genes: ASF1A ASF1B ATRX BPTF BRD4 BRD7 CARM1 CHD1 CREBBP DCAF1 EP300 ESR1 HMGB2 HPF1 KAT2B KMT2A MAPK9 NEDD4 NOS3 PARP1 PARP10 PARP2 PELP1 PIM1 PPM1D PPP1CA PPP1CB SET SETD7 SMARCA1 SMARCA4 SMARCA5 SS18 SSRP1 SUPT16H SUV39H1 TLE2 ZMYND11
Entrez ID		27043	3020
HPRD ID		10144	03082
Ensembl ID		ENSG00000141456	ENSG00000163041
Uniprot IDs		B4DEX7 B4DR36 C9JFV4 E7EV54 Q8IZL8	B2R4P9 P84243
PDB IDs			2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 3WTP 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58 4N4I 4O62 4QQ4 4TMP 4U7T 4W5A 5B32 5B33 5BNV 5BNX 5DWQ 5DX0 5JA4 5JJY 5JLB 5KDM 5X7X 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6HGT 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6QXZ 6R0C 6RNY 6U04
Enriched GO Terms of Interacting Partners?
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