HEYL and SP8

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		HEYL	SP8
Description		hes related family bHLH transcription factor with YRPW motif like	Sp8 transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity AF-1 Domain Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Outflow Tract Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Anterior/posterior Pattern Specification Mesenchymal Cell Development Cell Differentiation Glomerulus Development Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Cardiac Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Notch Signaling Involved In Heart Development Cellular Response To BMP Stimulus Proximal Tubule Development Circulatory System Development	Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Embryonic Limb Morphogenesis
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Red blood cell traits ( 23222517) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Alcohol consumption (drinks per week) ( 30643258) Bipolar I disorder ( 20386566) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Prostate cancer ( 23535732) Response to statin therapy ( 20339536) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: APP ATF7IP ATXN1 HAND1 HAND2 HIPK3 HTT LAPTM5 MDFI PPP1CA RBPMS RPGRIP1 SKIL SMAD3 SMAD7 SMAD9 SP8 ZNF512B	3 interacting genes: HEYL ZNF273 ZNF519
Entrez ID		26508	221833
HPRD ID		16419	12208
Ensembl ID		ENSG00000163909	ENSG00000164651
Uniprot IDs		Q9NQ87	A8K350 Q8IXZ3
PDB IDs
Enriched GO Terms of Interacting Partners?
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