SEZ6L2 and UNG

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SEZ6L2	UNG
Description		seizure related 6 homolog like 2	uracil DNA glycosylase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Mitochondrion
	Molecular Function		Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Ribosomal Small Subunit Binding
	Biological Process		DNA Repair Base-excision Repair Viral Process Somatic Hypermutation Of Immunoglobulin Genes Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Pathways
Drugs			CID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases			Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Anthropometric traits ( 19260139) Autism spectrum disorder or schizophrenia ( 28540026) Bitter alcoholic beverage consumption ( 31046077) Body fat distribution (arm fat ratio) ( 30664634) Response to taxane treatment (placlitaxel) ( 23006423) Schizophrenia ( 28991256 25056061 29483656) Systemic lupus erythematosus ( 23273568)	Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		6 interacting genes: ETV5 FOXA1 MTDH OASL TK1 UNG	5 interacting genes: APP CAPN11 PCNA RPA2 SEZ6L2
Entrez ID		26470	7374
HPRD ID		06686	01881
Ensembl ID		ENSG00000174938	ENSG00000076248
Uniprot IDs		A0A087WYL5 A0A0A8K8P7 B7Z5L4 Q6UXD5	E5KTA5 E5KTA6 P13051
PDB IDs			1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7
Enriched GO Terms of Interacting Partners?
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