NECTIN3 and TIGIT

Number of citations of the paper that reports this interaction (PubMedID 21982860)
16

Data Source:
BioGRID (pull down)

		NECTIN3	TIGIT
Description		nectin cell adhesion molecule 3	T cell immunoreceptor with Ig and ITIM domains
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Axon Dendrite Apical Junction Complex Cell-cell Contact Zone Hippocampal Mossy Fiber To CA3 Synapse Integral Component Of Postsynaptic Density Membrane	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity Protein Homodimerization Activity Cell Adhesion Molecule Binding	Signaling Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Spermatid Development Fertilization Adherens Junction Organization Retina Morphogenesis In Camera-type Eye Establishment Of Protein Localization To Plasma Membrane Protein Localization To Cell Junction	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of T Cell Activation
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS		Feeling hurt ( 29500382)
Interacting Genes		13 interacting genes: AFDN KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 NECTIN1 NECTIN2 NOTCH2NLA PARD3 PVR RGS20 TIGIT	4 interacting genes: NECTIN2 NECTIN3 NECTIN4 PVR
Entrez ID		25945	201633
HPRD ID		08454	08804
Ensembl ID		ENSG00000177707	ENSG00000181847
Uniprot IDs		Q9NQS3	Q495A1
PDB IDs		4FOM	3Q0H 3RQ3 3UCR 3UDW 5V52
Enriched GO Terms of Interacting Partners?
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