RCHY1 and TMBIM1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		RCHY1	TMBIM1
Description		ring finger and CHY zinc finger domain containing 1	transmembrane BAX inhibitor motif containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle	Lysosomal Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Integral Component Of Membrane Specific Granule Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity	Death Receptor Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Error-free Translesion Synthesis	Negative Regulation Of Catalytic Activity Neutrophil Degranulation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Fas Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Remodeling
Pathways		Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)	Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Gallstone disease ( 30504769) High light scatter reticulocyte count ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		69 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA2 HOXB1 HOXB5 HOXC4 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MDM2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPLP1 RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160	2 interacting genes: RCHY1 SOCS5
Entrez ID		25898	64114
HPRD ID		07607	17884
Ensembl ID		ENSG00000163743	ENSG00000135926
Uniprot IDs		Q96PM5	A0A024R472 B3KSM0 B4DUD2 Q969X1
PDB IDs		2JRJ 2K2C 2K2D
Enriched GO Terms of Interacting Partners?
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