SHC2 and RPL36

		SHC2	RPL36
Description		SHC adaptor protein 2	ribosomal protein L36
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane	Nucleolus Cytoplasm Cytosol Membrane Cytosolic Large Ribosomal Subunit Polysomal Ribosome
	Molecular Function	Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding	RNA Binding Structural Constituent Of Ribosome
	Biological Process	MAPK Cascade Activation Of MAPK Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription
Pathways		Signalling to RAS Signalling to RAS VEGFA-VEGFR2 Pathway RAF/MAP kinase cascade	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		8 interacting genes: ERBB2 FLT1 GRB2 KDR NTRK1 NTRK2 NTRK3 RPL36	10 interacting genes: APP APPL2 ARHGAP45 DAZAP1 KLHL4 NR2C2 PIP5K1C RPL18A SHC2 TESC
Entrez ID		25759	25873
HPRD ID		19296	10201
Ensembl ID		ENSG00000129946	ENSG00000130255
Uniprot IDs		P98077	Q9Y3U8
PDB IDs			4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
Enriched GO Terms of Interacting Partners?
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