NPNT and ITGA8

Number of citations of the paper that reports this interaction (PubMedID 11470831)
70

Data Source:
HPRD (in vitro, in vivo)

		NPNT	ITGA8
Description		nephronectin	integrin subunit alpha 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Smooth Muscle Contractile Fiber Integrin Alpha8-beta1 Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Postsynaptic Density Dendritic Spine Membrane Integrin Alpha8-beta1 Complex Perikaryon Apical Part Of Cell
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding	Metal Ion Binding
	Biological Process	Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Cell-matrix Adhesion Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Adhesion Mediated By Integrin Establishment Of Protein Localization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Tumor Necrosis Factor Pilomotor Reflex Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation	Metanephros Development Kidney Development Cell-matrix Adhesion Integrin-mediated Signaling Pathway Brain Development Memory Cell Projection Organization Extracellular Matrix Organization Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Inner Ear Morphogenesis Establishment Of Protein Localization Mesodermal Cell Differentiation Smooth Muscle Tissue Development Cell-cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation
Pathways			Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 28166215 30804561) Copper levels ( 26025379) Diastolic blood pressure ( 27841878) FEV1 ( 30804560) Hypertension ( 30487518) Lung function (FEV1) ( 28166213 26635082) Lung function (FEV1/FVC) ( 28166213 26635082 30804560) Lung function (FVC) ( 28166213 30804560) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Night sleep phenotypes ( 27126917) Peak expiratory flow ( 30804560) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 27841878 30487518) Systolic blood pressure ( 28135244 27841878 28739976 30578418)	Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Diisocyanate-induced asthma ( 25918132) Parkinson's disease ( 19915575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (CDC/AAP) ( 24024966) Quantitative traits ( 19197348) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		1 interacting genes: ITGA8	4 interacting genes: FN1 ITGB1 NPNT VTN
Entrez ID		255743	8516
HPRD ID		14141	10361
Ensembl ID		ENSG00000168743	ENSG00000077943
Uniprot IDs		Q6UXI9	B4DN28 P53708
PDB IDs
Enriched GO Terms of Interacting Partners?
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