RICTOR and EIF4EBP1

Number of citations of the paper that reports this interaction (PubMedID 18606717)
434

Data Source:
BioGRID (enzymatic study)

		RICTOR	EIF4EBP1
Description		RPTOR independent companion of MTOR complex 2	eukaryotic translation initiation factor 4E binding protein 1
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GO Annotations	Cellular Component	Cytosol TORC2 Complex	Nucleus Cytoplasm Cytosol Protein-containing Complex Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Protein Binding Enzyme Activator Activity Protein Kinase Binding Ribosome Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Protein Phosphatase 2A Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Viral Process Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Positive Regulation Of Actin Filament Polymerization Establishment Or Maintenance Of Actin Cytoskeleton Polarity Actin Cytoskeleton Reorganization TOR Signaling Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Regulation Of GTPase Activity Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Kinase B Signaling Regulation Of Establishment Of Cell Polarity	G1/S Transition Of Mitotic Cell Cycle IRES-dependent Translational Initiation Of Linear MRNA Response To Ischemia Insulin Receptor Signaling Pathway Lung Development Negative Regulation Of Protein Complex Assembly TOR Signaling Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Response To Amino Acid Starvation
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation	mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245)	Menopause (age at onset) ( 29773799)
Interacting Genes		11 interacting genes: CHUK CUL1 EIF4EBP1 GSK3A GSK3B IKBKB ILK MTOR PLK1 SGK1 SIRT1	32 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 EIF4E EIF4E2 GSK3B IRAK4 LATS1 LRRK2 MAPK1 MAPK14 MAPKAPK5 MLST8 MTOR MVD PLAT PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4
Entrez ID		253260	1978
HPRD ID		10682	03746
Ensembl ID		ENSG00000164327	ENSG00000187840
Uniprot IDs		Q6R327	Q13541
PDB IDs		5ZCS	1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX
Enriched GO Terms of Interacting Partners?
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