FTL and SPINK7

Number of citations of the paper that reports this interaction (PubMedID 12646258)
8

Data Source:
BioGRID (two hybrid)

		FTL	SPINK7
Description		ferritin light chain	serine peptidase inhibitor Kazal type 7
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GO Annotations	Cellular Component	Extracellular Region Cell Cytoplasm Cytosol Intracellular Ferritin Complex Membrane Azurophil Granule Lumen Autolysosome Extracellular Exosome	Extracellular Region
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Identical Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Iron Ion Transport Cellular Iron Ion Homeostasis Intracellular Sequestering Of Iron Ion Neutrophil Degranulation Iron Ion Homeostasis	Negative Regulation Of Endopeptidase Activity
Pathways		Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport
Drugs		Iron Dextran Protoporphyrin Sodium ferric gluconate complex
Diseases		Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia
GWAS			Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382)
Interacting Genes		26 interacting genes: CLEC4G FTH1 GADD45A GLP1R GRB2 HTT IGDCC3 KNG1 KPNA3 MAP3K12 MPHOSPH6 MPP6 MTNR1B MYOC MYOG PIK3CA PPP1CC PTN RAP2A SDCBP SMAD9 SPINK7 TAF10 USHBP1 VKORC1 ZDHHC17	8 interacting genes: EPB42 FTL HBA1 MRPS12 MT1G MT1H MT2A RABL6
Entrez ID		2512	84651
HPRD ID		00616	16850
Ensembl ID		ENSG00000087086	ENSG00000145879
Uniprot IDs		A0A384MDR3 P02792	P58062
PDB IDs		2FFX 2FG4 2FG8 3KXU 4V6B 5LG8	2LEO
Enriched GO Terms of Interacting Partners?
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