IL17RA and IL17A

Number of citations of the paper that reports this interaction (PubMedID 9367539)
51

Data Source:
HPRD (in vivo, in vitro)

		IL17RA	IL17A
Description		interleukin 17 receptor A	interleukin 17A
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Interleukin-17 Receptor Activity	Cytokine Activity Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-23 Production Defense Response To Fungus Granulocyte Chemotaxis Fibroblast Activation Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Interleukin-5 Secretion Positive Regulation Of Interleukin-13 Secretion	Apoptotic Process Inflammatory Response Immune Response Cell-cell Signaling Cell Death Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-23 Production Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Fungus Cellular Response To Interleukin-1 Fibroblast Activation Interleukin-17-mediated Signaling Pathway Granulocyte Migration Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Interleukin-6 Secretion
Pathways		Interleukin-17 signaling	Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling
Drugs			Secukinumab Ixekizumab
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Blood protein levels ( 30072576 29875488 28240269) Granulocyte percentage of myeloid white cells ( 27863252) Heschl's gyrus morphology ( 25130324) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Non-alcoholic fatty liver disease activity score ( 31311600) White blood cell count ( 27863252)	Height ( 28552196)
Interacting Genes		7 interacting genes: BCL2L13 BID IL17A MTDH POTEH PTPRT TESK1	2 interacting genes: DPH2 IL17RA
Entrez ID		23765	3605
HPRD ID		10399	04396
Ensembl ID		ENSG00000177663	ENSG00000112115
Uniprot IDs		Q96F46	Q16552
PDB IDs		3JVF 4HSA 4NUX 5N9B 5NAN	2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5 5N7W 5N92 5NAN 5VB9
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?