PADI4 and FBXO25

Number of citations of the paper that reports this interaction (PubMedID 23940030)
5

Data Source:
BioGRID (enzymatic study)

		PADI4	FBXO25
Description		peptidyl arginine deiminase 4	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Arginine Binding Identical Protein Binding	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Cellular Protein Modification Process Protein Citrullination Stem Cell Population Maintenance Histone H3-R26 Citrullination Histone Citrullination Innate Immune Response	Protein Ubiquitination
Pathways		Chromatin modifying enzymes
Drugs		L-Citrulline Azithromycin Doxycycline Tetracycline Streptomycin N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE
Diseases
GWAS		Basal cell carcinoma ( 18849993) IgA nephropathy ( 25305756) Rheumatoid arthritis ( 21452313 21505073 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		8 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 NPM1 SMURF1	82 interacting genes: ANKRD13A APLF AXL BMX C19orf57 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		23569	26260
HPRD ID		05635	16439
Ensembl ID		ENSG00000159339	ENSG00000147364
Uniprot IDs		Q9UM07	A0A024QZ88 Q8TCJ0
PDB IDs		1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B
Enriched GO Terms of Interacting Partners?
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