PSD4 and LDLRAP1

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		PSD4	LDLRAP1
Description		pleckstrin and Sec7 domain containing 4	low density lipoprotein receptor adaptor protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Cleavage Furrow Ruffle Membrane	Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Vesicle Membrane Recycling Endosome
	Molecular Function	ARF Guanyl-nucleotide Exchange Factor Activity Phospholipid Binding	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Receptor Signaling Complex Scaffold Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Regulation Of ARF Protein Signal Transduction	Receptor-mediated Endocytosis Cholesterol Metabolic Process Positive Regulation Of Signal Transduction Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Membrane Organization Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance
Drugs
Diseases
GWAS		Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Diastolic blood pressure ( 28548082) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Red blood cell count ( 27863252)	Cholesterol, total ( 24097068 25961943 20686565) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Mean platelet volume ( 27863252) Platelet count ( 27863252) Total cholesterol levels ( 28334899)
Interacting Genes		2 interacting genes: LDLRAP1 USP9X	9 interacting genes: AP2B1 APP C6orf58 CLTC LDLR LRP2 MAPK8IP3 PSD4 TFAP2A
Entrez ID		23550	26119
HPRD ID		15191	05765
Ensembl ID		ENSG00000125637	ENSG00000157978
Uniprot IDs		Q8NDX1	B3KR97 Q5SW96
PDB IDs			2G30
Enriched GO Terms of Interacting Partners?
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