ETHE1 and IGSF21

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ETHE1	IGSF21
Description		ETHE1 persulfide dioxygenase	immunoglobin superfamily member 21
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix	Adherens Junction Anchored Component Of External Side Of Plasma Membrane Presynaptic Membrane Postsynaptic Membrane Inhibitory Synapse
	Molecular Function	Iron Ion Binding Hydrolase Activity, Acting On Ester Bonds Sulfur Dioxygenase Activity	Signaling Receptor Activity Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Glutathione Metabolic Process Sulfide Oxidation, Using Sulfide:quinone Oxidoreductase Hydrogen Sulfide Metabolic Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Maturation
Pathways		Sulfide oxidation to sulfate
Drugs
Diseases
GWAS			Atypical femoral fracture in phosphonate treatment ( 31006051) Cobalt levels ( 26025379) Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Survival in pancreatic cancer ( 28470677)
Interacting Genes		5 interacting genes: APP ATP6V1H IGSF21 LRIF1 RELA	32 interacting genes: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		23474	84966
HPRD ID		09764	11309
Ensembl ID		ENSG00000105755	ENSG00000117154
Uniprot IDs		A0A0S2Z580 A0A0S2Z5B3 A0A0S2Z5N8 B2RCZ7 O95571	Q96ID5
PDB IDs		4CHL
Enriched GO Terms of Interacting Partners?
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