SF3B1 and PLRG1

Number of citations of the paper that reports this interaction (PubMedID 22365833)
132

Data Source:
BioGRID (two hybrid, two hybrid)

		SF3B1	PLRG1
Description		splicing factor 3b subunit 1	pleiotropic regulator 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U11/U12 SnRNP U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Prp19 Complex Fibrillar Center Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Speck Nuclear Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Splicing Factor Binding	Protein Binding
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Positive Regulation Of Gene Expression, Epigenetic	MRNA Splicing, Via Spliceosome Protein Localization To Nucleus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Major depressive disorder ( 27479909) Morning person ( 30696823) Schizophrenia ( 25056061 29483656 30285260)	Fibrinogen ( 21757653) Fibrinogen levels ( 29403010 28107422)
Interacting Genes		24 interacting genes: APBB1 C11orf58 CALM1 CLK1 CSNK2A1 DYRK1A ERG IL7R MELK MYC NUDT21 PLRG1 PPP1R8 PRPF40A SF1 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 TCERG1 TOP1 WBP4	7 interacting genes: APP CDC5L CNN1 HNRNPM MX1 SF3B1 ZSCAN1
Entrez ID		23451	5356
HPRD ID		09281	16181
Ensembl ID		ENSG00000115524	ENSG00000171566
Uniprot IDs		B4DGZ4 O75533	O43660
PDB IDs		2F9D 2F9J 2FHO 2PEH 3LQV 4OZ1 5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6N3E 6QX9	4YVD 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV
Enriched GO Terms of Interacting Partners?
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