FNTB and GBP1

Number of citations of the paper that reports this interaction (PubMedID 10676968)
95

Data Source:
HPRD (in vitro)

		FNTB	GBP1
Description		farnesyltransferase, CAAX box, beta	guanylate binding protein 1
Image
GO Annotations	Cellular Component	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex	Golgi Membrane Extracellular Region Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Vesicle Membrane Actin Cytoskeleton Cytoplasmic Vesicle
	Molecular Function	Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding	Actin Binding GTPase Activity Protein Binding GTP Binding GDP Binding Enzyme Binding Cytokine Binding Spectrin Binding Identical Protein Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Protein Prenylation Protein Farnesylation Regulation Of Rhodopsin Mediated Signaling Pathway	Regulation Of Calcium-mediated Signaling Negative Regulation Of T Cell Receptor Signaling Pathway Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Protein Localization To Vacuole Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Interleukin-2 Secretion Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Interferon gamma signaling
Drugs		AZD3409 Tipifarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID FARNESYL DIPHOSPHATE Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 27863252 28017375 19862010) Mean platelet volume ( 27863252) Metabolite levels ( 23823483) Platelet count ( 27863252) Red blood cell count ( 27863252) Red blood cell traits ( 23222517)	Remission after SSRI treatment in MDD or openness ( 29559929)
Interacting Genes		9 interacting genes: CENPF FNTA GBP1 HDAC6 HRAS KRAS PTP4A3 RAP2A RRAS2	3 interacting genes: FNTA FNTB PTBP2
Entrez ID		2342	2633
HPRD ID		00608	02681
Ensembl ID		ENSG00000257365	ENSG00000117228
Uniprot IDs		A0A384MEJ5 P49356	P32455
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	1DG3 1F5N 2B8W 2B92 2BC9 2D4H 6K1Z 6K2D
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?