FNTA and KRAS

Number of citations of the paper that reports this interaction (PubMedID 12374986)
50

Data Source:
HPRD (in vitro)

		FNTA	KRAS
Description		farnesyltransferase, CAAX box, alpha	KRAS proto-oncogene, GTPase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex	Cytoplasm Mitochondrion Cytosol Plasma Membrane Focal Adhesion Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft
	Molecular Function	Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Acetylcholine Receptor Regulator Activity Receptor Tyrosine Kinase Binding Alpha-tubulin Binding	GTPase Activity Protein Binding GTP Binding GMP Binding GDP Binding LRR Domain Binding Protein-containing Complex Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Protein Farnesylation Protein Geranylgeranylation Regulation Of Rhodopsin Mediated Signaling Pathway Neurotransmitter Receptor Metabolic Process Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Deacetylase Activity Regulation Of Neurotransmitter Receptor Activity	MAPK Cascade Liver Development Positive Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Ras Protein Signal Transduction Female Pregnancy Positive Regulation Of Cell Proliferation Visual Learning Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Forebrain Astrocyte Development Actin Cytoskeleton Organization Regulation Of Protein Stability Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Response To Isolation Stress Endocrine Signaling Positive Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Differentiation Regulation Of Long-term Neuronal Synaptic Plasticity Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Response To Glucocorticoid Response To Mineralocorticoid Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Cellular Senescence
Pathways		Apoptotic cleavage of cellular proteins Inactivation, recovery and regulation of the phototransduction cascade	Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF RUNX3 regulates p14-ARF RAS GTPase cycle mutants Signaling downstream of RAS mutants
Drugs		AZD3409 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID FARNESYL DIPHOSPHATE Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE	[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID FARNESYL DIPHOSPHATE
Diseases			Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Pancreatic cancer Gastric cancer Colorectal cancer Non-small cell lung cancer Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Oral cancer Acute myeloid leukemia (AML) Endometrial Cancer Multiple myeloma Squamous cell carcinoma Kaposi's sarcoma Cholangiocarcinoma Thyroid cancer Cervical cancer Hepatocellular carcinoma Ovarian cancer Gallbladder cancer
GWAS		Zinc levels ( 26025379)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Dysmenorrheic pain ( 27454463)
Interacting Genes		17 interacting genes: ACVR1 CENPF FNTB GBP1 HDAC6 HRAS INHBB KRAS PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2	55 interacting genes: ADH6 ARAF ARL6IP5 BCAS3 BCL2 BRAF CALM1 CCL5 CCT7 DDX47 DDX50 DIRAS3 DNAJA3 EGLN1 EPB42 FNTA FNTB HNRNPC HRAS IGSF21 IL24 LPAR1 LYPD4 LZTR1 MDFI MOCS2 MT-CO3 MT-CYB NDUFA13 OSGIN1 PDE4DIP PGGT1B PIK3CA PIK3CG PIK3R2 PIP5K1A PSMA3 QDPR RAF1 RALGDS RAP1GDS1 RASGRF2 RASGRP2 RASSF2 RASSF5 RBPMS RGL2 SERPINB5 SHOC2 SOX4 THRSP TNFSF13 UQCRC1 WDR76 ZDHHC17
Entrez ID		2339	3845
HPRD ID		00607	01817
Ensembl ID		ENSG00000168522	ENSG00000133703
Uniprot IDs		P49354	A0A024RAV5 I1SRC5 L7RSL8 P01116
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	1D8D 1D8E 1KZO 1KZP 1N4P 1N4Q 1N4R 1N4S 2MSC 2MSD 2MSE 3GFT 4DSN 4DSO 4EPR 4EPT 4EPV 4EPW 4EPX 4EPY 4L8G 4LDJ 4LPK 4LRW 4LUC 4LV6 4LYF 4LYH 4LYJ 4M1O 4M1S 4M1T 4M1W 4M1Y 4M21 4M22 4NMM 4OBE 4PZY 4PZZ 4Q01 4Q02 4Q03 4QL3 4TQ9 4TQA 4WA7 5F2E 5KYK 5MLA 5MLB 5O2S 5O2T 5OCG 5OCO 5OCT 5TAR 5TB5 5UFE 5UFQ 5UK9 5UQW 5US4 5USJ 5V6S 5V6V 5V71 5V9L 5V9O 5V9U 5VBM 5VP7 5VPI 5VPY 5VPZ 5VQ0 5VQ1 5VQ2 5VQ6 5VQ8 5W22 5WHA 5WHB 5WHD 5WHE 5WLB 5WPM 5XCO 5YXZ 5YY1 6ARK 6ASA 6ASE 6B0V 6B0Y 6BOF 6BP1 6CC9 6CCH 6CCX 6CU6 6E6F 6E6G 6EPL 6EPM 6EPN 6EPO 6EPP 6F76 6FA1 6FA2 6FA3 6FA4 6GJ5 6GJ6 6GJ7 6GJ8 6GOD 6GOE 6GOF 6GOG 6GOM 6GQT 6GQW 6GQX 6GQY 6H46 6H47 6M9W 6MBQ 6MBT 6MBU 6MQG 6MQN 6N2J 6N2K 6OB2 6OB3 6OIM 6P0Z 6P8W 6P8X 6P8Y 6P8Z 6QUU 6QUV 6QUW 6QUX
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?