SASH1 and SNX1

Number of citations of the paper that reports this interaction (PubMedID 30480076)
2

Data Source:
BioGRID (two hybrid)

		SASH1	SNX1
Description		SAM and SH3 domain containing 1	sorting nexin 1
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GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex	Cytoplasm Lysosome Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Vesicle Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Autoubiquitination	Intracellular Protein Transport Receptor Internalization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Lamellipodium Morphogenesis
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN	25 interacting genes: ACVR1B ACVR2B AGTRAP APP ARFIP2 ARL6IP1 ATXN7 CMTM5 EGFR F2R FUNDC1 HGS INSR LEPR PDGFRB RABAC1 REEP6 RTN3 RTN4 SASH1 SNX2 SNX6 TK1 UFD1 VPS35
Entrez ID		23328	6642
HPRD ID		06408	03171
Ensembl ID		ENSG00000111961	ENSG00000028528
Uniprot IDs		O94885	Q13596
PDB IDs		2DL0 2EBP	2I4K 4FZS
Enriched GO Terms of Interacting Partners?
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