USP22 and RCAN1

Number of citations of the paper that reports this interaction (PubMedID 25546086)
4

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		USP22	RCAN1
Description		ubiquitin specific peptidase 22	regulator of calcineurin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleoplasm SAGA-type Complex	Nucleus Cytoplasm
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Nuclear Receptor Transcription Coactivator Activity	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Embryo Development Ending In Birth Or Egg Hatching Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle	Regulation Of Transcription, DNA-templated Signal Transduction Central Nervous System Development Blood Circulation Calcineurin-NFAT Signaling Cascade Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		HATs acetylate histones Ub-specific processing proteases
Drugs			Dipyridamole
Diseases
GWAS		Body mass index ( 26426971) Mosquito bite size ( 28199695)	Cancer ( 29299148) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		12 interacting genes: ATXN7 H2AC20 H2BC21 HEXA MRPL10 MRPL44 MYC PSME1 PTGS2 RCAN1 SCFD1 UBC	8 interacting genes: APP BTRC GSK3B MAP3K3 MAPK3 PPP3CA USP22 UXT
Entrez ID		23326	1827
HPRD ID		19411	04226
Ensembl ID		ENSG00000124422	ENSG00000159200
Uniprot IDs		Q9UPT9	B7Z1F0 E9PDJ2 P53805 Q6FGP2 Q6ZMM3 V9GYW9
PDB IDs
Enriched GO Terms of Interacting Partners?
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