SMG6 and SMG5

Number of citations of the paper that reports this interaction (PubMedID 12699629)
61

Data Source:
HPRD (in vitro, in vivo)

		SMG6	SMG5
Description		SMG6 nonsense mediated mRNA decay factor	SMG5 nonsense mediated mRNA decay factor
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol
	Molecular Function	RNA Binding Endoribonuclease Activity Protein Binding Telomeric DNA Binding Ribonucleoprotein Complex Binding Metal Ion Binding Telomerase RNA Binding DNA Polymerase Binding	Protein Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Histone Deacetylase Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation Regulation Of Telomerase Activity RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Negative Regulation Of Telomere Capping	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Grn163l
Diseases
GWAS		Aortic root size ( 19584346) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28892062 25673413) Calcaneus stiffness index ( 30779856) Cannabis use ( 30150663) Coronary artery disease ( 29212778 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Esophageal cancer (squamous cell) ( 22960999) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414 22504420) Forehead morphology ( 29921221) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998 29235454) Metabolite levels (5-HIAA) ( 23319000) Mitral valve prolapse ( 26301497) Monocyte count ( 27863252) Multiple sclerosis ( 31604244) Myocardial infarction ( 26343387) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 27863252) Plateletcrit ( 27863252) Pulse pressure ( 27841878) Schizophrenia ( 25056061 29483656) Smoking initiation ( 30617275) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 31420334) White blood cell count ( 27863252)	Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978)
Interacting Genes		3 interacting genes: PPP1CC SMG5 TERT	7 interacting genes: APP SMG1 SMG6 SMG7 STUB1 TERT UPF1
Entrez ID		23293	23381
HPRD ID		06502	16869
Ensembl ID		ENSG00000070366	ENSG00000198952
Uniprot IDs		Q86US8	Q9UPR3
PDB IDs		2DOK 2HWW 2HWX 4UM2	2HWY
Enriched GO Terms of Interacting Partners?
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