ARHGEF9 and PLEKHA5

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		ARHGEF9	PLEKHA5
Description		Cdc42 guanine nucleotide exchange factor 9	pleckstrin homology domain containing A5
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GO Annotations	Cellular Component	Cytosol Postsynaptic Density Cell Junction	Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction	Biological_process Reproductive System Development
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events GABA receptor activation GABA receptor activation	Synthesis of PIPs at the plasma membrane
Drugs
Diseases		Hyperekplexia Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Male-pattern baldness ( 28196072)	Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Thalamus volume ( 31530798)
Interacting Genes		7 interacting genes: BCL6 GPHN IHO1 KHDRBS1 PLEKHA5 SMURF1 TFIP11	36 interacting genes: ADK ARHGEF9 BET1 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 H2AJ KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 RECQL SH3BP5L SOGA1 SPIRE1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		23229	54477
HPRD ID		02337	09684
Ensembl ID		ENSG00000131089	ENSG00000052126
Uniprot IDs		B1AMR3 O43307	A0A024RAY7 Q9HAU0
PDB IDs		2YSQ	2DKP
Enriched GO Terms of Interacting Partners?
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