FLI1 and ETV6

Number of citations of the paper that reports this interaction (PubMedID 9651344)
32

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		FLI1	ETV6
Description		Fli-1 proto-oncogene, ETS transcription factor	ETS variant transcription factor 6
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body	Nuclear Chromatin Nucleus Nucleolus Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Hemostasis Blood Circulation Animal Organ Morphogenesis Cell Differentiation Megakaryocyte Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Vitellogenesis Neurogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Proliferation Mesenchymal Cell Apoptotic Process
Pathways		Transcriptional regulation of granulopoiesis	Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Drugs
Diseases		Ewing's sarcoma	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Corneal astigmatism ( 30306274) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Heel bone mineral density ( 30598549) Height ( 20881960 31562340) Left ventricular obstructive tract defect (inherited effect) ( 28468790) Myopia (pathological) ( 23049088) Non-albumin protein levels ( 29403010) Platelet count ( 27863252) Plateletcrit ( 27863252) Rheumatoid arthritis ( 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 26502338) Vitiligo ( 27723757)	Asthma ( 27611488) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Colorectal cancer ( 27145994) Height ( 28552196 20881960 25282103 23563607 31562340 18391951) Night sleep phenotypes ( 27126917) Phosphorus levels ( 29403010)
Interacting Genes		18 interacting genes: BRCA1 CTBP2 ELK1 ERG ETV6 EWSR1 GATA1 KLF1 PIAS1 PIAS2 PRKCD SIAH1 SMAD3 SMAD9 SOX30 SRF TDP2 UBE2I	17 interacting genes: AP1M1 AXIN1 CRKL FBXL6 FLI1 GAB2 GRB2 HDAC9 KAT5 L3MBTL1 NTAQ1 PIN1 SIN3A SMURF1 SUMO1 TRAF2 UBE2I
Entrez ID		2313	2120
HPRD ID		01901	15976
Ensembl ID		ENSG00000151702	ENSG00000139083
Uniprot IDs		A0A024R3K4 A0A024R3M5 A0A024R3N6 Q01543	A0A0S2Z3C9 P41212
PDB IDs		1FLI 1X66 2YTU 5E8G 5E8I 5JVT	1JI7 1LKY 2DAO 2QAR 2QB0 2QB1 5L0P
Enriched GO Terms of Interacting Partners?
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