ARHGAP26 and PKN1

Number of citations of the paper that reports this interaction (PubMedID 11432776)
15

Data Source:
HPRD (in vitro, in vivo)

		ARHGAP26	PKN1
Description		Rho GTPase activating protein 26	protein kinase N1
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GO Annotations	Cellular Component	Cellular_component Cytosol Cytoskeleton Focal Adhesion	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex
	Molecular Function	GTPase Activator Activity Protein Binding Phospholipid Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding
	Biological Process	Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Spleen Development Positive Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Motility
Pathways		Rho GTPase cycle	RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Coronary artery disease ( 29212778) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878) Waist circumference ( 28552196)	Urolithiasis ( 30975718)
Interacting Genes		8 interacting genes: CDC42 CDC42EP2 INSR PKN1 PKN3 PTK2 RHOA SRPK1	39 interacting genes: ACTN1 AKAP9 ARHGAP10 ARHGAP26 BUD23 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 H3C14 HDAC5 HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MTDH NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM ZFAND6 ZNF282
Entrez ID		23092	5585
HPRD ID		05643	03019
Ensembl ID		ENSG00000145819	ENSG00000123143
Uniprot IDs		A0A0S2Z536 Q9UNA1	Q16512
PDB IDs		1UGV	1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?
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