SORCS3 and NGF

Number of citations of the paper that reports this interaction (PubMedID 15710408)
10

Data Source:
HPRD (in vitro)

		SORCS3	NGF
Description		sortilin related VPS10 domain containing receptor 3	nerve growth factor
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Extracellular Region Extracellular Space Golgi Lumen Cytosol Synaptic Vesicle Axon Dendrite Cytoplasmic Vesicle Endosome Lumen
	Molecular Function	Neuropeptide Receptor Activity	Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Lipid Binding
	Biological Process	Neuropeptide Signaling Pathway Learning Memory Regulation Of Long-term Synaptic Depression	Activation Of MAPKK Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peripheral Nervous System Development Memory Negative Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Nerve Development Nerve Growth Factor Processing Nerve Growth Factor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission
Pathways			PLC-gamma1 signalling Signalling to RAS NGF processing NGF processing Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling PI3K/AKT activation PI3K/AKT activation Signalling to STAT3 NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation
Drugs			Clenbuterol RI 624
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 29700475) Diabetic kidney disease ( 26305897) Diastolic blood pressure ( 30224653) Feeling miserable ( 29500382) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Mood instability ( 31168069) Multisite chronic pain ( 31194737) Non-alcoholic fatty liver disease activity score ( 31311600) Rosacea symptom severity ( 29771307) Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan) ( 28521775) Systolic blood pressure ( 30578418)	Diastolic blood pressure ( 27841878) Dysmenorrheic pain ( 27454463) Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Migraine ( 27182965 27322543) Migraine without aura ( 27322543) Obstetric antiphospholipid syndrome ( 28424481) Pain medicine use during menstruation ( 29855537) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Schizophrenia ( 30285260) Systolic blood pressure ( 27841878)
Interacting Genes		2 interacting genes: IDE NGF	8 interacting genes: A2M CRYAB MMP7 NGFR NTRK1 PLG SORCS3 SORT1
Entrez ID		22986	4803
HPRD ID		12100	08874
Ensembl ID		ENSG00000156395	ENSG00000134259
Uniprot IDs		Q86XB2 Q9UPU3	A0A346FYQ1 P01138
PDB IDs			1SG1 1WWW 2IFG 4EDW 4EDX 4ZBN 5JZ7
Enriched GO Terms of Interacting Partners?
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