ANKRD6 and AXIN2

Number of citations of the paper that reports this interaction (PubMedID 12183362)
65

Data Source:
HPRD (in vivo, two hybrid)

		ANKRD6	AXIN2
Description		ankyrin repeat domain 6	axin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Centrosome Cytosol Beta-catenin Destruction Complex
	Molecular Function		Protein Binding Beta-catenin Binding Enzyme Binding Ubiquitin Protein Ligase Binding I-SMAD Binding
	Biological Process	Positive Regulation Of JNK Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Somitogenesis Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Odontogenesis Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways			TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases
Drugs
Diseases			Tooth agenesis; Hypodontia Oligodontia-colorectal cancer syndrome
GWAS		Bipolar disorder ( 25827505) Coronary artery disease ( 29212778) Knee osteoarthritis ( 28916551) Metabolite levels (Pyroglutamine) ( 23934736) vWF and FVIII levels ( 21810271) Waist-hip ratio ( 28552196)	Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549 28869591) Height ( 31562340)
Interacting Genes		2 interacting genes: AXIN2 CSNK1E	9 interacting genes: ANKRD6 APC APC2 CSNK1E CTNNB1 GSK3B SLC9A3R1 SMAD3 SMAD7
Entrez ID		22881	8313
HPRD ID		09798	04935
Ensembl ID		ENSG00000135299	ENSG00000168646
Uniprot IDs		B7Z3D2 Q9Y2G4	E7ES00 Q9Y2T1
PDB IDs
Enriched GO Terms of Interacting Partners?
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