NLGN1 and NRXN2

Number of citations of the paper that reports this interaction (PubMedID 8576240)
152

Data Source:
BioGRID (pull down)

		NLGN1	NRXN2
Description		neuroligin 1	neurexin 2
Image
GO Annotations	Cellular Component	Cell Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Cell Junction Dendrite Filopodium Tip Synaptic Cleft Dendritic Spine Dendritic Shaft Receptor Complex Synapse Excitatory Synapse Spanning Component Of Membrane Presynapse Postsynapse Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane	Plasma Membrane Integral Component Of Membrane Presynapse
	Molecular Function	Amyloid-beta Binding PDZ Domain Binding Signaling Receptor Activity Neurexin Family Protein Binding Identical Protein Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding Scaffold Protein Binding	Transmembrane Signaling Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Protein Targeting Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Chemical Synaptic Transmission Nervous System Development Synapse Assembly Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Synaptic Vesicle Targeting Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuronal Signal Transduction Neuron Projection Development Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Establishment Of Protein Localization Regulation Of Neuron Differentiation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Rhythmic Process Cytoskeletal Matrix Organization At Active Zone Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Morphogenesis Cellular Response To Calcium Ion Terminal Button Organization Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Neurexin Clustering Involved In Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Postsynaptic Specialization Assembly Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Presynapse Assembly Synaptic Membrane Adhesion Neuron Projection Arborization Positive Regulation Of Ruffle Assembly Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Protein Localization To Synapse Positive Regulation Of Intracellular Signal Transduction Excitatory Synapse Assembly Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering	Neuron Cell-cell Adhesion Signal Transduction Chemical Synaptic Transmission Neurotransmitter Secretion Synapse Assembly Adult Behavior Social Behavior Vocal Learning Vocalization Behavior Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Adverse response to drug ( 30420678) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Hand grip strength ( 29691431) Major depressive disorder ( 20516156) Metabolite levels ( 23823483) Motion sickness ( 25628336) Periodontitis (DPAL) ( 24024966) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Waist-to-hip ratio adjusted for BMI ( 28552196) Weight ( 28552196)	Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 29273807) Post bronchodilator FEV1 in COPD ( 26634245) Serum uric acid levels ( 30993211 29403010) Urate levels ( 21768215 23263486) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 29558500)
Interacting Genes		6 interacting genes: DLG2 DLG3 DLG4 NRXN1 NRXN2 NRXN3	9 interacting genes: AFDN CASK DDX24 MACF1 MAPK6 NLGN1 NLGN2 NLGN3 PATJ
Entrez ID		22871	9379
HPRD ID		07195	11859
Ensembl ID		ENSG00000169760	ENSG00000110076
Uniprot IDs		Q8N2Q7	G5E9G7 P58401 Q9P2S2
PDB IDs		5OJ6 5OJK	4NXR
Enriched GO Terms of Interacting Partners?
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