FGF12 and DPPA2

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		FGF12	DPPA2
Description		fibroblast growth factor 12	developmental pluripotency associated 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Synapse	Nucleoplasm
	Molecular Function	Protein Binding Growth Factor Activity Sodium Channel Regulator Activity Ion Channel Binding	Chromatin Binding
	Biological Process	Regulation Of Membrane Depolarization Signal Transduction Cell-cell Signaling Chemical Synaptic Transmission Nervous System Development Heart Development Adult Locomotory Behavior Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transport Neuromuscular Process Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Neuronal Action Potential Regulation Of Sodium Ion Transmembrane Transport Regulation Of Voltage-gated Sodium Channel Activity Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity
Pathways		Phase 0 - rapid depolarisation
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 28552196) Idiopathic dilated cardiomyopathy ( 29495422) Ileal carcinoids ( 21139019) Major depressive disorder ( 23377640) Metabolite levels ( 19043545) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum metabolite concentrations in chronic kidney disease ( 29545352) Severe influenza A (H1N1) infection ( 26379185) Sleep quality ( 23728906)	Corneal astigmatism ( 23761726) Spatial memory ( 31596458)
Interacting Genes		18 interacting genes: AP2M1 APP COIL DACH1 DCTD DPPA2 IKZF1 LZTS2 MAPK13 MAPK8IP2 NEDD4 NEDD4L PJA1 SMURF1 SRPK1 SRPK2 YWHAE ZNF460	18 interacting genes: AP2M1 DPPA4 DVL2 DVL3 EIF1AD FGF12 FXR2 MCM10 MOAP1 PBXIP1 PLOD3 SDCBP2 SETD5 SPOP U2AF2 VTA1 ZCCHC10 ZNF250
Entrez ID		2257	151871
HPRD ID		03303	13248
Ensembl ID		ENSG00000114279	ENSG00000163530
Uniprot IDs		P61328	Q7Z7J5
PDB IDs		1Q1U 4JQ0
Enriched GO Terms of Interacting Partners?
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