FGF4 and NRP1

Number of citations of the paper that reports this interaction (PubMedID 15695515)
56

Data Source:
HPRD (in vitro)

		FGF4	NRP1
Description		fibroblast growth factor 4	neuropilin 1
Image
GO Annotations	Cellular Component	Extracellular Region	Semaphorin Receptor Complex Extracellular Space Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Cell Surface Axon Growth Cone Cytoplasmic Vesicle Mitochondrial Membrane Neuron Projection Neuronal Cell Body Receptor Complex Sorting Endosome Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding	Vascular Endothelial Growth Factor-activated Receptor Activity GTPase Activator Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Protein Kinase Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding
	Biological Process	MAPK Cascade Cartilage Condensation Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Mesenchymal Cell Proliferation Stem Cell Population Maintenance Embryonic Hindlimb Morphogenesis Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Cranial Suture Morphogenesis Apoptotic Process Involved In Morphogenesis Chondroblast Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Leukemia Inhibitory Factor Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Integrin-mediated Signaling Pathway Cell-cell Signaling Axon Guidance Axonal Fasciculation Response To Wounding Animal Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Retinal Ganglion Cell Axon Guidance Actin Cytoskeleton Reorganization Regulation Of Cdc42 Protein Signal Transduction Substrate Adhesion-dependent Cell Spreading Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration Neuropilin Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Positive Regulation Of GTPase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Cytokine Activity Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Motor Neuron Migration Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Postsynapse Organization Basal Dendrite Development Basal Dendrite Arborization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neural Crest Cell Migration Involved In Autonomic Nervous System Development Toxin Transport Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Involved In Axon Guidance Protein Localization To Early Endosome Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Otic Placode Development Positive Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer	Neurophilin interactions with VEGF and VEGFR Signaling by ROBO receptors Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Signal transduction by L1 CHL1 interactions
Drugs		Pentosan Polysulfate Heparin TP-508	Palifermin Pegaptanib
Diseases
GWAS		Birth weight ( 31043758) Breast cancer ( 20453838) Craniofacial microsomia ( 26853712) Urate levels in overweight individuals ( 25811787)	Blood protein levels ( 30072576 29875488) Coronary artery disease ( 29212778) Migraine ( 27322543) Schizophrenia ( 21682944) Small cell lung carcinoma ( 28604730) Tetralogy of Fallot ( 23297363)
Interacting Genes		5 interacting genes: FGFR1 FGFR2 FGFR3 FGFR4 NRP1	23 interacting genes: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 PLXNB1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F TGFBR1 TGFBR2 TGFBR3 VEGFA VEGFB
Entrez ID		2249	8829
HPRD ID		01294	03642
Ensembl ID		ENSG00000075388	ENSG00000099250
Uniprot IDs		P08620	A8K9V7 O14786 Q59F20 Q68DN3 Q6AWA9 Q6X907
PDB IDs		1IJT	1KEX 2QQI 2QQM 2QQN 3I97 4DEQ 4RN5 5C7G 5IJR 5IYY 5J1X 5JGI 5JGQ 5JHK 5L73 6FMC 6FMF
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?