JAZF1 and NR2C2

Number of citations of the paper that reports this interaction (PubMedID 15302918)
27

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		JAZF1	NR2C2
Description		JAZF zinc finger 1	nuclear receptor subfamily 2 group C member 2
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcriptional Repressor Complex	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding Transcription Corepressor Activity Protein Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Signaling Receptor Activity Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Spermatogenesis Nervous System Development Cell Differentiation Positive Regulation Of Embryonic Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways			Nuclear Receptor transcription pathway
Drugs
Diseases		Type II diabetes mellitus
GWAS		Alanine transaminase levels ( 29403010) Alcoholic chronic pancreatitis ( 28754779) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 31361310 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23128233) Eosinophilic esophagitis ( 29904099) FEV1 ( 30804560) Free thyroxine concentration ( 24722205) Gout ( 22179738) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 19343178 23563607 18952825) Hip circumference adjusted for BMI ( 25673412) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lung function (FVC) ( 30804560) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Medication use (drugs used in diabetes) ( 31015401) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244 24076602) Peak expiratory flow ( 30804560) Prostate cancer ( 18264096 31562322) Prostate-specific antigen levels ( 28139693) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 26606652 26502338 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systolic blood pressure ( 30224653 30578418) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Type 2 diabetes ( 27189021 22885922 18372903 24509480 30054458 26961502 29358691 30297969 31118516 20581827 28869590) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412 28448500)	Alcohol and nicotine co-dependence ( 22488850)
Interacting Genes		3 interacting genes: NR2C2 PPARG RXRA	23 interacting genes: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RAC1 RPL36 RXRB TAB1 TAB2 TRAF2
Entrez ID		221895	7182
HPRD ID		09373	03253
Ensembl ID		ENSG00000153814	ENSG00000177463
Uniprot IDs		Q86VZ6	F2YGU2 P49116
PDB IDs			3P0U
Enriched GO Terms of Interacting Partners?
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