FCGR3A and FCGR1A

Number of citations of the paper that reports this interaction (PubMedID 7516890)
11

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		FCGR3A	FCGR1A
Description		Fc fragment of IgG receptor IIIa	Fc fragment of IgG receptor Ia
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	IgG Binding	Protein Binding IgG Binding
	Biological Process	Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Receptor-mediated Endocytosis Phagocytosis, Engulfment Immune Response Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis	Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis
Drugs		Cetuximab Etanercept Immune Globulin Human Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Sarilumab Benralizumab	Cetuximab Etanercept Immune Globulin Human Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Methyl aminolevulinate Sarilumab
Diseases		NK cell defects, including the following disease: CD16 deficiency Systemic lupus erythematosus
GWAS		Birth weight ( 31043758) Blood protein levels ( 28240269) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Inflammatory bowel disease ( 28067908 23128233) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 30498034 23830517) Ulcerative colitis ( 28067908)
Interacting Genes		18 interacting genes: APCS APP CD247 CD38 CD4 FCER1G FCGR1A GP6 IGHG1 LCK PRKCA PRKCI PTPRC S100A4 SHC1 SYK ZAP70 ZBTB25	10 interacting genes: APCS CRKL CRP FCAR FCGR3A HCK HRG LAT LILRB2 SYK
Entrez ID		2214	2209
HPRD ID		00903	00904
Ensembl ID		ENSG00000203747	ENSG00000150337
Uniprot IDs		M9MML0 P08637	P12314
PDB IDs		3AY4 3SGJ 3SGK 3WN5 5BW7 5D6D 5ML9 5MN2 5VU0 5XJE 5XJF 5YC5	3RJD 4W4O 4X4M 4ZNE
Enriched GO Terms of Interacting Partners?
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