ZUP1 and RPS21

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ZUP1	RPS21
Description		zinc finger containing ubiquitin peptidase 1	ribosomal protein S21
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleoplasm Rough Endoplasmic Reticulum Cytosol Small Ribosomal Subunit Cytosolic Small Ribosomal Subunit Polysomal Ribosome Synapse
	Molecular Function	Nucleic Acid Binding Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein N-terminus Binding
	Biological Process	Proteolysis	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Colorectal cancer ( 26965516) Colorectal cancer or advanced adenoma ( 30510241) Prostate cancer ( 23535732)
Interacting Genes		6 interacting genes: CDKN2A CLN8 PRMT5 RPS21 SHCBP1 UBC	4 interacting genes: APP LBP RPSA ZUP1
Entrez ID		221302	6227
HPRD ID		12840	01605
Ensembl ID		ENSG00000153975	ENSG00000171858
Uniprot IDs		A0A0S2Z644 Q96AP4	P63220 Q6FGH5
PDB IDs		6EI1 6FGE	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6G18 6G4S 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
Enriched GO Terms of Interacting Partners?
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